Bulges calculated in the supercomputer: How cells digest their internal canal system

Inside cells, there exists an extensive system of canals known as the endoplasmic reticulum (ER), which consists of membrane-encased tubes that are partially broken down as needed — for instance in case of a nutrient deficiency. As part of this process, bulges or protrusions form in the membrane, which then pinch off and are recycled by the cell. A study has examined this protrusion process using computer simulations. Its finding: certain structural motifs of proteins in the ER membrane play a central role in this process.
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